Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

BE0000377ProteinHumansHADH

Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10) (PubMed:10231530, PubMed:11489939, PubMed:16725361). It is acted on by 4 drugs in DrugBank.

Gene name
HADH
UniProtKB entry
Q16836Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
314 residues · 34,293 Da
Also known as
1.1.1.35 · HAD · HAD1 · HADHSC · HCDH

Resolves to

Protein
UniProtQ16836UniProt nameHCDH_HUMAN
Gene
HGNCHGNC:4799NCBI Gene3033GenBank1483511GeneCardsHADH
Pharmacology
KEGGhsa:3033
Structure
PDB1F0YPDB1F12PDB1F14
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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6GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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