Guided entry of tail-anchored proteins factor CAMLG

BE0000379ProteinHumansCAMLG

Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (PubMed:23041287, PubMed:24392163, PubMed:27226539). It is acted on by 4 drugs in DrugBank.

Gene name
CAMLG
UniProtKB entry
P49069Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
296 residues · 32,952 Da
Also known as
Calcium signal-modulating cyclophilin ligand · CAML · GET2

Resolves to

Protein
UniProtP49069UniProt nameCAMLG_HUMAN
Gene
HGNCHGNC:1471NCBI Gene819GenBank619670GeneCardsCAMLG
Pharmacology
KEGGhsa:819
Structure
PDB6SO5PDB8CR1PDB8CR2
Drugs

What you can answer from here — as of September 03, 2024

4DrugsApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Guided entry of tail-anchored proteins factor CAMLG, how selective are they, and which programs against it are still in active trials?

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