Peroxisomal multifunctional enzyme type 2

BE0000408ProteinHumansHSD17B4

Bifunctional enzyme acting on the peroxisomal fatty acid beta-oxidation pathway. It is acted on by 2 drugs in DrugBank.

Gene name
HSD17B4
UniProtKB entry
P51659Swiss-Prot
Cellular location
Peroxisome
Residues / weight
736 residues · 79,686 Da
Also known as
17-beta-HSD 4 · 17-beta-hydroxysteroid dehydrogenase 4 · D-bifunctional protein · DBP · EDH17B4

Resolves to

Protein
UniProtP51659UniProt nameDHB4_HUMAN
Gene
HGNCHGNC:5213NCBI Gene3295GenBank1050517GeneCardsHSD17B4
Pharmacology
KEGGhsa:3295
Structure
PDB1IKTPDB1S9CPDB1ZBQ
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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23+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Peroxisomal multifunctional enzyme type 2, how selective are they, and which programs against it are still in active trials?

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