5-aminolevulinate synthase, non-specific, mitochondrial

BE0000409ProteinHumansALAS1

Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products. It is acted on by 4 drugs in DrugBank.

Gene name
ALAS1
UniProtKB entry
P13196Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
640 residues · 70,580 Da
Also known as
2.3.1.37 · 5-aminolevulinic acid synthase 1 · ALAS-H · ALAS3 · ALASH

Resolves to

Protein
UniProtP13196UniProt nameHEM1_HUMAN
Gene
HGNCHGNC:396NCBI Gene211GenBank28583GeneCardsALAS1
Pharmacology
KEGGhsa:211
Drugs

What you can answer from here — as of September 03, 2024

4DrugsApproved to experimental, with action, bond type and pharmacological action
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17GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 5-aminolevulinate synthase, non-specific, mitochondrial, how selective are they, and which programs against it are still in active trials?

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