Ornithine aminotransferase, mitochondrial

BE0000424ProteinHumansOAT

Catalyzes the reversible interconversion of L-ornithine and 2-oxoglutarate to L-glutamate semialdehyde and L-glutamate. It is acted on by 4 drugs in DrugBank.

Gene name
OAT
UniProtKB entry
P04181Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
439 residues · 48,534 Da
Also known as
2.6.1.13 · Ornithine delta-aminotransferase · Ornithine--oxo-acid aminotransferase

Resolves to

Protein
UniProtP04181UniProt nameOAT_HUMAN
Gene
HGNCHGNC:8091NCBI Gene4942GenBank189329GeneCardsOAT
Pharmacology
KEGGhsa:4942
Structure
PDB1GBNPDB1OATPDB2BYJ
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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31+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Ornithine aminotransferase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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