4-hydroxyphenylpyruvate dioxygenase

BE0000455ProteinHumansHPD

Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism (PubMed:10942115, PubMed:1339442, PubMed:34047349, PubMed:37794595). It is acted on by 4 drugs in DrugBank.

Gene name
HPD
UniProtKB entry
P32754Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
393 residues · 44,964 Da
Also known as
1.13.11.27 · 4-hydroxyphenylpyruvic acid oxidase · 4HPPD · HPD · HPPDase

Resolves to

Protein
UniProtP32754UniProt nameHPPD_HUMAN
Gene
HGNCHGNC:5147NCBI Gene3242GenBank3860238GeneCardsHPD
Pharmacology
KEGGhsa:3242
Structure
PDB3ISQPDB5EC3PDB8IM2
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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23+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 4-hydroxyphenylpyruvate dioxygenase, how selective are they, and which programs against it are still in active trials?

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