Ectonucleotide pyrophosphatase/phosphodiesterase family member 1

BE0000457ProteinHumansENPP1

Nucleotide pyrophosphatase that generates diphosphate (PPi) and functions in bone mineralization and soft tissue calcification by regulating pyrophosphate levels (By similarity). It is acted on by 3 drugs in DrugBank.

Gene name
ENPP1
UniProtKB entry
P22413Swiss-Prot
Cellular location
Cell membrane
Residues / weight
925 residues · 104,924 Da
Also known as
Alkaline phosphodiesterase I · E-NPP 1 · M6S1 · Membrane component chromosome 6 surface marker 1 · NPPase

Resolves to

Protein
UniProtP22413UniProt nameENPP1_HUMAN
Gene
HGNCHGNC:3356NCBI Gene5167GenBank189650GeneCardsENPP1
Pharmacology
IUPHAR/GtoPdb3312KEGGhsa:5167
Structure
PDB2YS0PDB6WETPDB6WEU
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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26GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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33+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, how selective are they, and which programs against it are still in active trials?

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