Gamma-aminobutyric acid receptor subunit alpha-4

BE0000478ProteinHumansGABRA4

Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:35355020). It is acted on by 17 drugs in DrugBank.

Gene name
GABRA4
UniProtKB entry
P48169Swiss-Prot
Cellular location
Cell membrane
Residues / weight
554 residues · 61,623 Da
Also known as
GABA(A) receptor subunit alpha-4 · GABAAR subunit alpha-4

Resolves to

Protein
UniProtP48169UniProt nameGBRA4_HUMAN
Gene
HGNCHGNC:4078NCBI Gene2557GenBank905393GeneCardsGABRA4
Pharmacology
IUPHAR/GtoPdb407KEGGhsa:2557
Structure
PDB7QN5PDB7QN7PDB7QN9
Drugs

What you can answer from here — as of September 07, 2019

17DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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26+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Gamma-aminobutyric acid receptor subunit alpha-4, how selective are they, and which programs against it are still in active trials?

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