Low-density lipoprotein receptor

BE0000499ProteinHumansLDLR

Binds low density lipoprotein /LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. It is acted on by 6 drugs in DrugBank.

Gene name
LDLR
UniProtKB entry
P01130Swiss-Prot
Cellular location
Cell membrane
Residues / weight
860 residues · 95,375 Da
Also known as
LDL receptor

Resolves to

Protein
UniProtP01130UniProt nameLDLR_HUMAN
Gene
HGNCHGNC:6547NCBI Gene3949GenBank307121GeneCardsLDLR
Pharmacology
KEGGhsa:3949
Structure
PDB1AJJPDB1D2JPDB1F5Y
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
6Clinical trialsTrials of drugs acting on it, by phase and status
Sign in
30GO termsFunction, process and component, as structured annotations
Sign in
4Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
94+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Low-density lipoprotein receptor, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In