NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

BE0000500ProteinHumansNDUFS4

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. It is acted on by 1 drug in DrugBank.

Gene name
NDUFS4
UniProtKB entry
O43181Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
175 residues · 20,108 Da
Also known as
CI-18 kDa · CI-AQDQ · Complex I-18 kDa · Complex I-AQDQ · NADH-ubiquinone oxidoreductase 18 kDa subunit

Resolves to

Protein
UniProtO43181UniProt nameNDUS4_HUMAN
Gene
HGNCHGNC:7711NCBI Gene4724GenBank2655053GeneCardsNDUFS4
Pharmacology
KEGGhsa:4724
Structure
PDB5XTBPDB5XTDPDB5XTH
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which approved drugs act on NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial, how selective are they, and which programs against it are still in active trials?

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