Retinal dehydrogenase 2

BE0000513ProteinHumansALDH1A2

Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans-13,14-dihydroretinoate, respectively (PubMed:29240402, PubMed:33565183). It is acted on by 3 drugs in DrugBank.

Gene name
ALDH1A2
UniProtKB entry
O94788Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
518 residues · 56,723 Da
Also known as
1.2.1.36 · Aldehyde dehydrogenase family 1 member A2 · ALDH1A2 · RALDH 2 · RALDH(II)

Resolves to

Protein
UniProtO94788UniProt nameAL1A2_HUMAN
Gene
HGNCHGNC:15472NCBI Gene8854GenBank3970842GeneCardsALDH1A2
Pharmacology
KEGGhsa:8854
Structure
PDB4X2QPDB6ALJPDB6B5G
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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17GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Retinal dehydrogenase 2, how selective are they, and which programs against it are still in active trials?

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