2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial

BE0000518ProteinHumansGCAT

Pyridoxal phosphate (PLP) dependent enzyme, which catalyzes the cleavage of 2-amino-3-oxobutanoate to glycine and acetyl-CoA. It is acted on by 2 drugs in DrugBank.

Gene name
GCAT
UniProtKB entry
O75600Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
419 residues · 45,285 Da
Also known as
2.3.1.29 · AKB ligase · Aminoacetone synthase · Glycine acetyltransferase · KBL

Resolves to

Protein
UniProtO75600UniProt nameKBL_HUMAN
Gene
HGNCHGNC:4188NCBI Gene23464GenBank3342906GeneCardsGCAT
Pharmacology
KEGGhsa:23464
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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10+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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