Fumarate reductase flavoprotein subunit

BE0000548ProteinEscherichia coli (strain K12)frdA

Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; fumarate reductase is used during anaerobic growth, and succinate dehydrogenase is used during aerobic growth. It is acted on by 3 drugs in DrugBank.

Gene name
frdA
UniProtKB entry
P00363Swiss-Prot
Residues / weight
602 residues · 65,971 Da
Also known as
1.3.5.1 · 1.3.5.4 · QFR flavoprotein subunit · Quinol-fumarate reductase flavoprotein subunit

Resolves to

Protein
UniProtP00363UniProt nameFRDA_ECOLI
Gene
NCBI Gene948667GenBank145263
Pharmacology
KEGGecj:JW4115
Structure
PDB1KF6PDB1KFYPDB1L0V
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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12GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Fumarate reductase flavoprotein subunit, how selective are they, and which programs against it are still in active trials?

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