NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2

BE0000550ProteinHumansNDUFA2

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. It is acted on by 1 drug in DrugBank.

Gene name
NDUFA2
UniProtKB entry
O43678Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
99 residues · 10,921 Da
Also known as
CI-B8 · Complex I-B8 · NADH-ubiquinone oxidoreductase B8 subunit

Resolves to

Protein
UniProtO43678UniProt nameNDUA2_HUMAN
Gene
HGNCHGNC:7685NCBI Gene4695GenBank2909862GeneCardsNDUFA2
Pharmacology
KEGGhsa:4695
Structure
PDB1S3APDB5XTBPDB5XTD
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2, how selective are they, and which programs against it are still in active trials?

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