Retinol dehydrogenase 5

BE0000570ProteinHumansRDH5

Catalyzes the oxidation of cis-isomers of retinol, including 11-cis-, 9-cis-, and 13-cis-retinol in an NAD-dependent manner (PubMed:10588954, PubMed:11675386, PubMed:9115228, PubMed:9931293). It is acted on by 3 drugs in DrugBank.

Gene name
RDH5
UniProtKB entry
Q92781Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
318 residues · 34,978 Da
Also known as
1.1.1.209 · 1.1.1.315 · 1.1.1.53 · 11-cis RDH · 11-cis retinol dehydrogenase

Resolves to

Protein
UniProtQ92781UniProt nameRDH5_HUMAN
Gene
HGNCHGNC:9940NCBI Gene5959GenBank1616654GeneCardsRDH5
Pharmacology
KEGGhsa:5959
Drugs

What you can answer from here — as of September 03, 2024

3DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Retinol dehydrogenase 5, how selective are they, and which programs against it are still in active trials?

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