NADH-ubiquinone oxidoreductase chain 5

BE0000580ProteinHumansMT-ND5

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:15250827). It is acted on by 2 drugs in DrugBank.

Gene name
MT-ND5
UniProtKB entry
P03915Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
603 residues · 67,026 Da
Also known as
7.1.1.2 · MTND5 · NADH dehydrogenase subunit 5 · NADH5 · ND5

Resolves to

Protein
UniProtP03915UniProt nameNU5M_HUMAN
Gene
HGNCHGNC:7461NCBI Gene4540GenBank2052366GeneCardsMT-ND5
Pharmacology
KEGGhsa:4540
Structure
PDB5XTCPDB5XTDPDB5XTH
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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27+ReferencesStructured and connected to the statements they support
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Which approved drugs act on NADH-ubiquinone oxidoreductase chain 5, how selective are they, and which programs against it are still in active trials?

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