Retinaldehyde dehydrogenase 3

BE0000583ProteinHumansALDH1A3

Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans-13,14-dihydroretinoate, respectively (By similarity) (PubMed:27759097). It is acted on by 2 drugs in DrugBank.

Gene name
ALDH1A3
UniProtKB entry
P47895Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
512 residues · 56,108 Da
Also known as
1.2.1.36 · Aldehyde dehydrogenase 6 · Aldehyde dehydrogenase family 1 member A3 · ALDH1A3 · ALDH6

Resolves to

Protein
UniProtP47895UniProt nameAL1A3_HUMAN
Gene
HGNCHGNC:409NCBI Gene220GenBank544482GeneCardsALDH1A3
Pharmacology
KEGGhsa:220
Structure
PDB5FHZPDB6S6WPDB6TE5
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Retinaldehyde dehydrogenase 3, how selective are they, and which programs against it are still in active trials?

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