Peroxisomal bifunctional enzyme

BE0000586ProteinHumansEHHADH

Peroxisomal trifunctional enzyme possessing 2-enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase, and delta 3, delta 2-enoyl-CoA isomerase activities. It is acted on by 2 drugs in DrugBank.

Gene name
EHHADH
UniProtKB entry
Q08426Swiss-Prot
Cellular location
Peroxisome
Residues / weight
723 residues · 79,494 Da
Also known as
ECHD · L-bifunctional protein · LBP · MFE1 · Multifunctional enzyme 1

Resolves to

Protein
UniProtQ08426UniProt nameECHP_HUMAN
Gene
HGNCHGNC:3247NCBI Gene1962GenBank452045GeneCardsEHHADH
Pharmacology
KEGGhsa:1962
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Peroxisomal bifunctional enzyme, how selective are they, and which programs against it are still in active trials?

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