Asparagine--tRNA ligase, cytoplasmic

BE0000607ProteinHumansNARS1

Catalyzes the attachment of asparagine to tRNA(Asn) in a two-step reaction: asparagine is first activated by ATP to form Asn-AMP and then transferred to the acceptor end of tRNA(Asn) (PubMed:32738225, PubMed:32788587, PubMed:9421509). It is acted on by 1 drug in DrugBank.

Gene name
NARS1
UniProtKB entry
O43776Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
548 residues · 62,942 Da
Also known as
6.1.1.22 · AsnRS · Asparaginyl-tRNA synthetase · Asparaginyl-tRNA synthetase 1 · NARS

Resolves to

Protein
UniProtO43776UniProt nameSYNC_HUMAN
Gene
HGNCHGNC:7643NCBI Gene4677GenBank2764505GeneCardsNARS1
Pharmacology
KEGGhsa:4677
Structure
PDB4ZYAPDB5XIXPDB8H53
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Asparagine--tRNA ligase, cytoplasmic, how selective are they, and which programs against it are still in active trials?

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