Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial

BE0000609ProteinHumansPDHA2

Together with PDHB forms the heterotetrameric E1 subunit of the pyruvate dehydrogenase (PDH) complex in testis (PubMed:14638692). It is acted on by 1 drug in DrugBank.

Gene name
PDHA2
UniProtKB entry
P29803Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
388 residues · 42,933 Da
Also known as
1.2.4.1 · PDHAL · PDHE1-A type II

Resolves to

Protein
UniProtP29803UniProt nameODPAT_HUMAN
Gene
HGNCHGNC:8807NCBI Gene5161GenBank190790GeneCardsPDHA2
Pharmacology
KEGGhsa:5161
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial, how selective are they, and which programs against it are still in active trials?

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