Glycine dehydrogenase (decarboxylating), mitochondrial

BE0000618ProteinHumansGLDC

The glycine cleavage system catalyzes the degradation of glycine. It is acted on by 2 drugs in DrugBank.

Gene name
GLDC
UniProtKB entry
P23378Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
1,020 residues · 112,729 Da
Also known as
1.4.4.2 · GCSP · Glycine cleavage system P protein · Glycine decarboxylase · Glycine dehydrogenase (aminomethyl-transferring)

Resolves to

Protein
UniProtP23378UniProt nameGCSP_HUMAN
Gene
HGNCHGNC:4313NCBI Gene2731GenBank190287GeneCardsGLDC
Pharmacology
KEGGhsa:2731
Structure
PDB6I33PDB6I34PDB6I35
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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5GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glycine dehydrogenase (decarboxylating), mitochondrial, how selective are they, and which programs against it are still in active trials?

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