UDP-glucose 6-dehydrogenase

BE0000645ProteinHumansUGDH

Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (PubMed:21502315, PubMed:21961565, PubMed:22123821, PubMed:23106432, PubMed:25478983, PubMed:27966912, PubMed:30420606, PubMed:30457329). It is acted on by 2 drugs in DrugBank.

Gene name
UGDH
UniProtKB entry
O60701Swiss-Prot
Residues / weight
494 residues · 55,024 Da
Also known as
1.1.1.22 · UDP-Glc dehydrogenase · UDP-GlcDH · UDPGDH

Resolves to

Protein
UniProtO60701UniProt nameUGDH_HUMAN
Gene
HGNCHGNC:12525NCBI Gene7358GenBank3127127GeneCardsUGDH
Pharmacology
KEGGhsa:7358
Structure
PDB2Q3EPDB2QG4PDB3ITK
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which approved drugs act on UDP-glucose 6-dehydrogenase, how selective are they, and which programs against it are still in active trials?

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