NADH-ubiquinone oxidoreductase chain 2

BE0000655ProteinHumansMT-ND2

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:16996290). It is acted on by 1 drug in DrugBank.

Gene name
MT-ND2
UniProtKB entry
P03891Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
347 residues · 38,960 Da
Also known as
7.1.1.2 · MTND2 · NADH dehydrogenase subunit 2 · NADH2 · ND2

Resolves to

Protein
UniProtP03891UniProt nameNU2M_HUMAN
Gene
HGNCHGNC:7456NCBI Gene4536GenBank2052363GeneCardsMT-ND2
Pharmacology
KEGGhsa:4536
Structure
PDB5XTCPDB5XTDPDB5XTH
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which approved drugs act on NADH-ubiquinone oxidoreductase chain 2, how selective are they, and which programs against it are still in active trials?

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