Mineralocorticoid receptor

BE0000668ProteinHumansNR3C2

Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. It is acted on by 37 drugs in DrugBank.

Gene name
NR3C2
UniProtKB entry
P08235Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
984 residues · 107,081 Da
Also known as
MCR · MLR · MR · Nuclear receptor subfamily 3 group C member 2

Resolves to

Protein
UniProtP08235UniProt nameMCR_HUMAN
Gene
HGNCHGNC:7979NCBI Gene4306GenBank307166GeneCardsNR3C2
Pharmacology
IUPHAR/GtoPdb626KEGGhsa:4306
Structure
PDB1Y9RPDB1YA3PDB2A3I
Drugs

What you can answer from here — as of September 07, 2019

37DrugsApproved to experimental, with action, bond type and pharmacological action
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13GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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138+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Mineralocorticoid receptor, how selective are they, and which programs against it are still in active trials?

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