Myeloid cell surface antigen CD33

BE0000674ProteinHumansCD33

Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state (PubMed:10611343, PubMed:11320212, PubMed:15597323). It is acted on by 13 drugs in DrugBank.

Gene name
CD33
UniProtKB entry
P20138Swiss-Prot
Cellular location
Cell membrane
Residues / weight
364 residues · 39,825 Da
Also known as
gp67 · Sialic acid-binding Ig-like lectin 3 · Siglec-3 · SIGLEC3

Resolves to

Protein
UniProtP20138UniProt nameCD33_HUMAN
Gene
HGNCHGNC:1659NCBI Gene945GenBank180098GeneCardsCD33
Pharmacology
IUPHAR/GtoPdb2601KEGGhsa:945
Structure
PDB5IHBPDB5J06PDB5J0B
Drugs

What you can answer from here — as of September 07, 2019

13DrugsApproved to experimental, with action, bond type and pharmacological action
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30Clinical trialsTrials of drugs acting on it, by phase and status
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5GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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44+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Myeloid cell surface antigen CD33, how selective are they, and which programs against it are still in active trials?

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