5'-AMP-activated protein kinase catalytic subunit alpha-1

BE0000677ProteinHumansPRKAA1

Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:17307971, PubMed:17712357, PubMed:24563466, PubMed:31492851, PubMed:37821951, PubMed:40233740). It is acted on by 9 drugs in DrugBank.

Gene name
PRKAA1
UniProtKB entry
Q13131Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
559 residues · 64,009 Da
Also known as
2.7.11.1 · ACACA kinase · Acetyl-CoA carboxylase kinase · AMPK subunit alpha-1 · AMPK1

Resolves to

Protein
UniProtQ13131UniProt nameAAPK1_HUMAN
Gene
HGNCHGNC:9376NCBI Gene5562GenBank4115829GeneCardsPRKAA1
Pharmacology
KEGGhsa:5562
Structure
PDB4REDPDB4RERPDB4REW
Drugs

What you can answer from here — as of September 07, 2019

9DrugsApproved to experimental, with action, bond type and pharmacological action
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44GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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54+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 5'-AMP-activated protein kinase catalytic subunit alpha-1, how selective are they, and which programs against it are still in active trials?

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