Potassium channel subfamily K member 6

BE0000680ProteinHumansKCNK6

K(+) channel that conducts outward rectifying currents at the membranes of the endolysosomal system (PubMed:10887187, PubMed:28381826, PubMed:40343992, PubMed:41617707). It is acted on by 2 drugs in DrugBank.

Gene name
KCNK6
UniProtKB entry
Q9Y257Swiss-Prot
Cellular location
Late endosome membrane
Residues / weight
313 residues · 33,747 Da
Also known as
Inward rectifying potassium channel protein TWIK-2 · TOSS · TWIK-originated similarity sequence · TWIK2

Resolves to

Protein
UniProtQ9Y257UniProt nameKCNK6_HUMAN
Gene
HGNCHGNC:6281NCBI Gene9424GenBank4559312GeneCardsKCNK6
Pharmacology
KEGGhsa:9424
Structure
PDB9E94PDB9MEKPDB9MEL
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Potassium channel subfamily K member 6, how selective are they, and which programs against it are still in active trials?

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