Cysteine--tRNA ligase, cytoplasmic

BE0000701ProteinHumansCARS1

Catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys). It is acted on by 1 drug in DrugBank.

Gene name
CARS1
UniProtKB entry
P49589Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
748 residues · 85,473 Da
Also known as
6.1.1.16 · CARS · CysRS · Cysteinyl-tRNA synthetase

Resolves to

Protein
UniProtP49589UniProt nameSYCC_HUMAN
Gene
HGNCHGNC:1493NCBI Gene833GenBank927229GeneCardsCARS1
Pharmacology
KEGGhsa:833
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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1GO termFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cysteine--tRNA ligase, cytoplasmic, how selective are they, and which programs against it are still in active trials?

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