High affinity 3',5'-cyclic-AMP phosphodiesterase 7A

BE0000706ProteinHumansPDE7A

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:19350606, PubMed:8389765, PubMed:9195912). It is acted on by 2 drugs in DrugBank.

Gene name
PDE7A
UniProtKB entry
Q13946Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
482 residues · 55,504 Da
Also known as
3.1.4.53 · cAMP-specific phosphodiesterase 7A · HCP1 · TM22

Resolves to

Protein
UniProtQ13946UniProt namePDE7A_HUMAN
Gene
HGNCHGNC:8791NCBI Gene5150GenBank5566609GeneCardsPDE7A
Pharmacology
IUPHAR/GtoPdb1305KEGGhsa:5150
Structure
PDB1ZKLPDB3G3NPDB4PM0
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which compounds in development act on High affinity 3',5'-cyclic-AMP phosphodiesterase 7A, and which indications are they being tested in?

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