DNA polymerase alpha subunit B

BE0000716ProteinHumansPOLA2

Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis (PubMed:9705292). It is acted on by 1 drug in DrugBank.

Gene name
POLA2
UniProtKB entry
Q14181Swiss-Prot
Cellular location
Nucleus
Residues / weight
598 residues · 65,947 Da
Also known as
DNA polymerase alpha 70 kDa subunit

Resolves to

Protein
UniProtQ14181UniProt nameDPOA2_HUMAN
Gene
HGNCHGNC:30073NCBI Gene23649GenBank439601GeneCardsPOLA2
Pharmacology
KEGGhsa:23649
Structure
PDB2KEBPDB4E2IPDB4Y97
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on DNA polymerase alpha subunit B, how selective are they, and which programs against it are still in active trials?

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