T-cell surface antigen CD2

BE0000719ProteinHumansCD2

CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. It is acted on by 2 drugs in DrugBank.

Gene name
CD2
UniProtKB entry
P06729Swiss-Prot
Cellular location
Cell membrane
Residues / weight
351 residues · 39,448 Da
Also known as
Erythrocyte receptor · LFA-2 · LFA-3 receptor · Rosette receptor · SRBC

Resolves to

Protein
UniProtP06729UniProt nameCD2_HUMAN
Gene
HGNCHGNC:1639NCBI Gene914GenBank180081GeneCardsCD2
Pharmacology
KEGGhsa:914
Structure
PDB1CDBPDB1GYAPDB1HNF
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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15GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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25+ReferencesStructured and connected to the statements they support
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Which approved drugs act on T-cell surface antigen CD2, how selective are they, and which programs against it are still in active trials?

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