Aspartate--tRNA ligase, cytoplasmic

BE0000725ProteinHumansDARS1

Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor... It is acted on by 1 drug in DrugBank.

Gene name
DARS1
UniProtKB entry
P14868Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
501 residues · 57,136 Da
Also known as
6.1.1.12 · Aspartyl-tRNA synthetase · AspRS · Cell proliferation-inducing gene 40 protein · DARS

Resolves to

Protein
UniProtP14868UniProt nameSYDC_HUMAN
Gene
HGNCHGNC:2678NCBI Gene1615GenBank179102GeneCardsDARS1
Pharmacology
KEGGhsa:1615
Structure
PDB4J15PDB5Y6LPDB6IY6
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Aspartate--tRNA ligase, cytoplasmic, how selective are they, and which programs against it are still in active trials?

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