Pyrroline-5-carboxylate reductase 2

BE0000728ProteinHumansPYCR2

Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate to L-proline using NAD(P)H (PubMed:23024808, PubMed:2722838, PubMed:6894153). It is acted on by 2 drugs in DrugBank.

Gene name
PYCR2
UniProtKB entry
Q96C36Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
320 residues · 33,637 Da
Also known as
1.5.1.2 · P5C reductase 2 · P5CR 2

Resolves to

Protein
UniProtQ96C36UniProt nameP5CR2_HUMAN
Gene
HGNCHGNC:30262NCBI Gene29920GenBank33150582GeneCardsPYCR2
Pharmacology
KEGGhsa:29920
Structure
PDB6LHM
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Pyrroline-5-carboxylate reductase 2, how selective are they, and which programs against it are still in active trials?

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