Translocator protein

BE0000736ProteinHumansTSPO

Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). It is acted on by 42 drugs in DrugBank.

Gene name
TSPO
UniProtKB entry
P30536Swiss-Prot
Cellular location
Mitochondrion membrane
Residues / weight
169 residues · 18,828 Da
Also known as
BZRP · MBR · Mitochondrial benzodiazepine receptor · PBR · Peripheral-type benzodiazepine receptor

Resolves to

Protein
UniProtP30536UniProt nameTSPO_HUMAN
Gene
HGNCHGNC:1158NCBI Gene706GenBank306883GeneCardsTSPO
Pharmacology
IUPHAR/GtoPdb2879KEGGhsa:706
Drugs

What you can answer from here — as of September 07, 2019

42DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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14GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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100+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Translocator protein, how selective are they, and which programs against it are still in active trials?

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