Histidine--tRNA ligase, cytoplasmic

BE0000740ProteinHumansHARS1

Catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP) (PubMed:29235198). It is acted on by 2 drugs in DrugBank.

Gene name
HARS1
UniProtKB entry
P12081Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
509 residues · 57,410 Da
Also known as
6.1.1.21 · HARS · HisRS · Histidyl-tRNA synthetase · HRS

Resolves to

Protein
UniProtP12081UniProt nameHARS1_HUMAN
Gene
HGNCHGNC:4816NCBI Gene3035GenBank32460GeneCardsHARS1
Pharmacology
KEGGhsa:3035
Structure
PDB1X59PDB2LW7PDB4G84
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Histidine--tRNA ligase, cytoplasmic, how selective are they, and which programs against it are still in active trials?

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