NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12

BE0000754ProteinHumansNDUFA12

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. It is acted on by 1 drug in DrugBank.

Gene name
NDUFA12
UniProtKB entry
Q9UI09Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
145 residues · 17,114 Da
Also known as
13 kDa differentiation-associated protein · CI-B17.2 · CIB17.2 · Complex I-B17.2 · DAP13

Resolves to

Protein
UniProtQ9UI09UniProt nameNDUAC_HUMAN
Gene
HGNCHGNC:23987NCBI Gene55967GenBank9651637GeneCardsNDUFA12
Pharmacology
KEGGhsa:55967
Structure
PDB5XTBPDB5XTDPDB5XTH
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12, how selective are they, and which programs against it are still in active trials?

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