Arginase-2, mitochondrial

BE0000758ProteinHumansARG2

May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. It is acted on by 4 drugs in DrugBank.

Gene name
ARG2
UniProtKB entry
P78540Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
354 residues · 38,578 Da
Also known as
3.5.3.1 · Arginase II · Kidney-type arginase · Non-hepatic arginase · Type II arginase

Resolves to

Protein
UniProtP78540UniProt nameARGI2_HUMAN
Gene
HGNCHGNC:664NCBI Gene384GenBank1694633GeneCardsARG2
Pharmacology
IUPHAR/GtoPdb1245KEGGhsa:384
Structure
PDB1PQ3PDB4HZEPDB4I06
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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16GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Arginase-2, mitochondrial, how selective are they, and which programs against it are still in active trials?

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