N(G),N(G)-dimethylarginine dimethylaminohydrolase 1

BE0000766ProteinHumansDDAH1

Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. It is acted on by 4 drugs in DrugBank.

Gene name
DDAH1
UniProtKB entry
O94760Swiss-Prot
Residues / weight
285 residues · 31,122 Da
Also known as
3.5.3.18 · DDAH · DDAH-1 · DDAHI · Dimethylargininase-1

Resolves to

Protein
UniProtO94760UniProt nameDDAH1_HUMAN
Gene
HGNCHGNC:2715NCBI Gene23576GenBank4160666GeneCardsDDAH1
Pharmacology
IUPHAR/GtoPdb1247KEGGhsa:23576
Structure
PDB2JAIPDB2JAJPDB3I2E
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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22+ReferencesStructured and connected to the statements they support
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Which approved drugs act on N(G),N(G)-dimethylarginine dimethylaminohydrolase 1, how selective are they, and which programs against it are still in active trials?

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