Mu-type opioid receptor

BE0000770ProteinHumansOPRM1

Receptor for endogenous opioids such as beta-endorphin and endomorphin (PubMed:10529478, PubMed:12589820, PubMed:7891175, PubMed:7905839, PubMed:7957926, PubMed:9689128). It is acted on by 111 drugs in DrugBank.

Gene name
OPRM1
UniProtKB entry
P35372Swiss-Prot
Cellular location
Cell membrane
Residues / weight
400 residues · 44,779 Da
Also known as
hMOP · M-OR-1 · MOP · MOR-1 · MOR1

Resolves to

Protein
UniProtP35372UniProt nameOPRM_HUMAN
Gene
HGNCHGNC:8156NCBI Gene4988GenBank452073GeneCardsOPRM1
Pharmacology
IUPHAR/GtoPdb319KEGGhsa:4988
Structure
PDB8EF5PDB8EF6PDB8EFB
Drugs

What you can answer from here — as of September 07, 2019

111DrugsApproved to experimental, with action, bond type and pharmacological action
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27Clinical trialsTrials of drugs acting on it, by phase and status
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17GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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498+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Mu-type opioid receptor, how selective are they, and which programs against it are still in active trials?

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