Sphingosine-1-phosphate lyase 1

BE0000778ProteinHumansSGPL1

Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. It is acted on by 2 drugs in DrugBank.

Gene name
SGPL1
UniProtKB entry
O95470Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
568 residues · 63,523 Da
Also known as
4.1.2.27 · hSPL · KIAA1252 · S1PL · SP-lyase 1

Resolves to

Protein
UniProtO95470UniProt nameSGPL1_HUMAN
Gene
HGNCHGNC:10817NCBI Gene8879GenBank10129683GeneCardsSGPL1
Pharmacology
IUPHAR/GtoPdb2522KEGGhsa:8879
Structure
PDB4Q6RPDB8AYF
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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1Pfam domainDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sphingosine-1-phosphate lyase 1, how selective are they, and which programs against it are still in active trials?

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