Cystathionine gamma-lyase

BE0000791ProteinHumansCTH

Catalyzes the last step in the trans-sulfuration pathway from L-methionine to L-cysteine in a pyridoxal-5'-phosphate (PLP)-dependent manner, which consists on cleaving the L,L-cystathionine molecule into L-cysteine, ammonia and 2-oxobutanoate (PubMed:10212249, PubMed:18476726, PubMed:19261609, PubMed:19961860). It is acted on by 7 drugs in DrugBank.

Gene name
CTH
UniProtKB entry
P32929Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
405 residues · 44,508 Da
Also known as
4.4.1.1 · CGL · CSE · Cysteine desulfhydrase · Cysteine-protein sulfhydrase

Resolves to

Protein
UniProtP32929UniProt nameCGL_HUMAN
Gene
HGNCHGNC:2501NCBI Gene1491GenBank262476GeneCardsCTH
Pharmacology
IUPHAR/GtoPdb1444KEGGhsa:1491
Structure
PDB2NMPPDB3COGPDB3ELP
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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12GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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26+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cystathionine gamma-lyase, how selective are they, and which programs against it are still in active trials?

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