Isoleucine--tRNA ligase

BE0000804ProteinStaphylococcus aureusileS

Catalyzes the attachment of isoleucine to tRNA(Ile). It is acted on by 1 drug in DrugBank.

Gene name
ileS
UniProtKB entry
P41972Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
917 residues · 104,884 Da
Also known as
6.1.1.5 · IleRS · Isoleucyl-tRNA synthetase

Resolves to

Protein
UniProtP41972UniProt nameSYI1_STAAU
Gene
GenBank437916
Structure
PDB1FFYPDB1QU2PDB1QU3
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Isoleucine--tRNA ligase, how selective are they, and which programs against it are still in active trials?

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