Glutathione S-transferase A4

BE0000811ProteinHumansGSTA4

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. It is acted on by 1 drug in DrugBank.

Gene name
GSTA4
UniProtKB entry
O15217Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
222 residues · 25,704 Da
Also known as
2.5.1.18 · Glutathione S-transferase A4-4 · GST class-alpha member 4

Resolves to

Protein
UniProtO15217UniProt nameGSTA4_HUMAN
Gene
HGNCHGNC:4629NCBI Gene2941GenBank2597924GeneCardsGSTA4
Pharmacology
KEGGhsa:2941
Structure
PDB1GULPDB1GUMPDB3IK7
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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1GO termFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glutathione S-transferase A4, how selective are they, and which programs against it are still in active trials?

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