Glutathione peroxidase 2

BE0000817ProteinHumansGPX2

Catalyzes the reduction of hydroperoxides in a glutathione-dependent manner thus regulating cellular redox homeostasis (PubMed:36608588, PubMed:8428933). It is acted on by 1 drug in DrugBank.

Gene name
GPX2
UniProtKB entry
P18283Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
190 residues · 21,954 Da
Also known as
1.11.1.9 · Gastrointestinal glutathione peroxidase · Glutathione peroxidase-gastrointestinal · Glutathione peroxidase-related protein 2 · GPRP-2

Resolves to

Protein
UniProtP18283UniProt nameGPX2_HUMAN
Gene
HGNCHGNC:4554NCBI Gene2877GenBank4902773GeneCardsGPX2
Pharmacology
KEGGhsa:2877
Structure
PDB2HE3
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glutathione peroxidase 2, how selective are they, and which programs against it are still in active trials?

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