Epididymal secretory glutathione peroxidase

BE0000820ProteinHumansGPX5

Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. It is acted on by 1 drug in DrugBank.

Gene name
GPX5
UniProtKB entry
O75715Swiss-Prot
Cellular location
Secreted
Residues / weight
221 residues · 25,202 Da
Also known as
1.11.1.9 · EGLP · Epididymis-specific glutathione peroxidase-like protein · Glutathione peroxidase 5 · GPx-5

Resolves to

Protein
UniProtO75715UniProt nameGPX5_HUMAN
Gene
HGNCHGNC:4557NCBI Gene2880GenBank3288455GeneCardsGPX5
Pharmacology
KEGGhsa:2880
Structure
PDB2I3Y
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Epididymal secretory glutathione peroxidase, how selective are they, and which programs against it are still in active trials?

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