Adrenocorticotropic hormone receptor

BE0000848ProteinHumansMC2R

G protein-coupled receptor for corticotropin/ACTH, primarily expressed in adrenal cortex where it plays a key role in the regulation of adrenocortical function (PubMed:1325670, PubMed:17596328, PubMed:36588120). It is acted on by 6 drugs in DrugBank.

Gene name
MC2R
UniProtKB entry
Q01718Swiss-Prot
Cellular location
Cell membrane
Residues / weight
297 residues · 33,926 Da
Also known as
ACTH receptor · ACTH-R · ACTHR · Adrenocorticotropin receptor · MC2-R

Resolves to

Protein
UniProtQ01718UniProt nameACTHR_HUMAN
Gene
HGNCHGNC:6930NCBI Gene4158GenBank28344GeneCardsMC2R
Pharmacology
IUPHAR/GtoPdb283KEGGhsa:4158
Structure
PDB8GY7PDB9K3L
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
1Clinical trialTrials of drugs acting on it, by phase and status
Sign in
4GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
34+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Adrenocorticotropic hormone receptor, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In