Receptor activity-modifying protein 1

BE0000859ProteinHumansRAMP1

Accessory protein that interacts with and modulates the function of G protein-coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL) and calcitonin receptor (CALCR) (PubMed:33602864, PubMed:9620797, PubMed:35324283, PubMed:38603770). It is acted on by 1 drug in DrugBank.

Gene name
RAMP1
UniProtKB entry
O60894Swiss-Prot
Cellular location
Cell membrane
Residues / weight
148 residues · 16,988 Da
Also known as
Calcitonin-receptor-like receptor activity-modifying protein 1 · CRLR activity-modifying protein 1

Resolves to

Protein
UniProtO60894UniProt nameRAMP1_HUMAN
Gene
HGNCHGNC:9843NCBI Gene10267GenBank3171910GeneCardsRAMP1
Pharmacology
IUPHAR/GtoPdb51KEGGhsa:10267
Structure
PDB2YX8PDB3N7PPDB3N7R
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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10+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Receptor activity-modifying protein 1, how selective are they, and which programs against it are still in active trials?

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