Receptor activity-modifying protein 1
Details
- Name
- Receptor activity-modifying protein 1
- Kind
- protein
- Synonyms
- Calcitonin-receptor-like receptor activity-modifying protein 1
- CRLR activity-modifying protein 1
- Gene Name
- RAMP1
- UniProtKB Entry
- O60894Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0010607|Receptor activity-modifying protein 1 MARALCRLPRRGLWLLLAHHLFMTTACQEANYGALLRELCLTQFQVDMEAVGETLWCDWG RTIRSYRELADCTWHMAEKLGCFWPNAEVDRFFLAVHGRYFRSCPISGRAVRDPPGSILY PFIVVPITVTLLVTALVVWQSKRTEGIV
- Number of residues
- 148
- Molecular Weight
- 16987.765
- Theoretical pI
- 8.29
- GO Classification
- Functionsamylin receptor activity / calcitonin gene-related peptide binding / calcitonin gene-related peptide receptor activityProcessesadenylate cyclase-activating G protein-coupled receptor signaling pathway / amylin receptor signaling pathway / calcitonin gene-related peptide receptor signaling pathway / G protein-coupled receptor signaling pathway / regulation of G protein-coupled receptor signaling pathwayComponentsCGRP receptor complex
- General Function
- Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL
- Specific Function
- amylin receptor activity
- Pfam Domain Function
- RAMP (PF04901)
- Signal Regions
- 1-26
- Transmembrane Regions
- 118-138
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0001711|447 bp ATGGCCCGGGCCCTGTGCCGCCTCCCGCGGCGCGGCCTCTGGCTGCTCCTGGCCCATCAC CTCTTCATGACCACTGCCTGCCAGGAGGCTAACTACGGTGCCCTCCTCCGGGAGCTCTGC CTCACCCAGTTCCAGGTAGACATGGAGGCCGTCGGGGAGACGCTGTGGTGTGACTGGGGC AGGACCATCAGGAGCTACAGGGAGCTGGCCGACTGCACCTGGCACATGGCGGAGAAGCTG GGCTGCTTCTGGCCCAATGCAGAGGTGGACAGGTTCTTCCTGGCAGTGCATGGCCGCTAC TTCAGGAGCTGCCCCATCTCAGGCAGGGCCGTGCGGGACCCGCCCGGCAGCATCCTCTAC CCCTTCATCGTGGTCCCCATCACGGTGACCCTGCTGGTGACGGCACTGGTGGTCTGGCAG AGCAAGCGCACTGAGGGCATTGTGTAG
- Chromosome Location
- 2
- Locus
- 2q37.3
- External Identifiers
Resource Link UniProtKB ID O60894 UniProtKB Entry Name RAMP1_HUMAN GenBank Protein ID 3171910 GenBank Gene ID AJ001014 GeneCard ID RAMP1 GenAtlas ID RAMP1 HGNC ID HGNC:9843 PDB ID(s) 2YX8, 3N7P, 3N7R, 3N7S, 4RWG, 5V6Y, 6D1U, 6E3Y, 6UMG, 6ZHO, 6ZIS, 7KNT, 7KNU, 7P0F, 7P0I, 7TYF, 7TYW, 8AX5, 8AX6, 8AX7, 9AUC KEGG ID hsa:10267 IUPHAR/Guide To Pharmacology ID 51 NCBI Gene ID 10267 - General References
- McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM: RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature. 1998 May 28;393(6683):333-9. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Kusano S, Kukimoto-Niino M, Akasaka R, Toyama M, Terada T, Shirouzu M, Shindo T, Yokoyama S: Crystal structure of the human receptor activity-modifying protein 1 extracellular domain. Protein Sci. 2008 Nov;17(11):1907-14. doi: 10.1110/ps.036012.108. Epub 2008 Aug 25. [Article]
- ter Haar E, Koth CM, Abdul-Manan N, Swenson L, Coll JT, Lippke JA, Lepre CA, Garcia-Guzman M, Moore JM: Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism. Structure. 2010 Sep 8;18(9):1083-93. doi: 10.1016/j.str.2010.05.014. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Pramlintide approved, investigational yes target agonist Details