Trifunctional purine biosynthetic protein adenosine-3

BE0000882ProteinHumansGART

Trifunctional enzyme that catalyzes three distinct reactions as part of the 'de novo' inosine monophosphate biosynthetic pathway. It is acted on by 7 drugs in DrugBank.

Gene name
GART
UniProtKB entry
P22102Swiss-Prot
Residues / weight
1,010 residues · 107,766 Da
Also known as
PGFT · PRGS

Resolves to

Protein
UniProtP22102UniProt namePUR2_HUMAN
Gene
HGNCHGNC:4163NCBI Gene2618GenBank31642GeneCardsGART
Pharmacology
KEGGhsa:2618
Structure
PDB1MEJPDB1MENPDB1MEO
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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12GO termsFunction, process and component, as structured annotations
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6Pfam domainsDomain architecture mapped to Pfam families and clans
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38+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Trifunctional purine biosynthetic protein adenosine-3, how selective are they, and which programs against it are still in active trials?

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