Acyl-CoA (8-3)-desaturase

BE0000888ProteinHumansFADS1

Acts as a front-end fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 5 located between a preexisting double bond and the carboxyl end of the fatty acyl chain. It is acted on by 6 drugs in DrugBank.

Gene name
FADS1
UniProtKB entry
O60427Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
444 residues · 51,964 Da
Also known as
1.14.19.44 · D5D · Delta-5 desaturase · Delta(5) desaturase · Delta(5) fatty acid desaturase

Resolves to

Protein
UniProtO60427UniProt nameFADS1_HUMAN
Gene
HGNCHGNC:3574NCBI Gene3992GenBank3169158GeneCardsFADS1
Pharmacology
KEGGhsa:3992
Drugs

What you can answer from here — as of September 03, 2024

6DrugsApproved to experimental, with action, bond type and pharmacological action
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2Metabolic reactionsDrug transformations it catalyses, substrate to product
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3GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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24+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Acyl-CoA (8-3)-desaturase, how selective are they, and which programs against it are still in active trials?

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