5-aminolevulinate synthase, erythroid-specific, mitochondrial

BE0000898ProteinHumansALAS2

Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products (PubMed:14643893, PubMed:21252495, PubMed:21309041, PubMed:21653323, PubMed:32499479, PubMed:34492704). It is acted on by 2 drugs in DrugBank.

Gene name
ALAS2
UniProtKB entry
P22557Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
587 residues · 64,633 Da
Also known as
2.3.1.37 · 5-aminolevulinic acid synthase 2 · ALAS-E · ALASE · ASB

Resolves to

Protein
UniProtP22557UniProt nameHEM0_HUMAN
Gene
HGNCHGNC:397NCBI Gene212GenBank28586GeneCardsALAS2
Pharmacology
KEGGhsa:212
Structure
PDB5QQQPDB5QQRPDB5QQS
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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27+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 5-aminolevulinate synthase, erythroid-specific, mitochondrial, how selective are they, and which programs against it are still in active trials?

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